2. Signaling Pathways
  3. GPCR/G Protein
  4. Angiotensin Receptor

Angiotensin Receptor

Angiotensin Receptor

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Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor Isoform Specific Products:

Angiotensin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-19072
    BRL-36378
    		Activator
    BRL-36378 is an ACE inhibitor that inhibits angiotensin-converting enzyme activity. BRL-36378 can be used in ligand-based virtual screening to identify new leading structures for chemical optimization.
    BRL-36378
  • HY-P0205
    Saralasin
    		Antagonist
    Saralasin ([Sar1,Ala8] Angiotensin II) is an octapeptide analog of angiotensin II. Saralasin is a competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension.
    Saralasin
  • HY-78168
    Azilsartan methyl ester
    		Antagonist
    Azilsartan methyl ester, a derivative of Azilsartan (HY-14914), is an angiotensin II receptor antagonist that plays an important role in hypertension.
    Azilsartan methyl ester
  • HY-A0250R
    Tasosartan (Standard)
    		Antagonist
    Tasosartan (Standard) is the analytical standard of Tasosartan. This product is intended for research and analytical applications. Tasosartan is a long-acting angiotensin II (AngII) receptor antagonist.
    Tasosartan (Standard)
  • HY-17004R
    Olmesartan (Standard)
    		Antagonist
    Olmesartan (Standard) is the analytical standard of Olmesartan. This product is intended for research and analytical applications. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.
    Olmesartan (Standard)
  • HY-123226
    TA-606
    		Antagonist
    TA-606 is a potent and orally active angiotensin II-receptor antagonist. TA-606 shows antihypertensive efficacy. TA-606 can be used for hypertension research.
    TA-606
  • HY-145552S
    Azilsartan mepixetil-d5
    		Antagonist
    Azilsartan mepixetil-d5 (QR-01019-d5) is deuterium labeled Azilsartan mepixetil. Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A).
    Azilsartan mepixetil-d<sub>5</sub>
  • HY-117805
    UR-7247
    		Antagonist
    UR-7247 is a potent and orally active angiotensin II AT1 receptor antagonist. UR-7247 decreases arterial pressure and increases renal blood flow.
    UR-7247
  • HY-19202
    rac-Olodanrigan
    		Antagonist
    rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT2 receptor antagonist with IC50s of 75.2 nM and 2918 nM for AT2R and AT1R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve.
    rac-Olodanrigan
  • HY-117743R
    Eprosartan (Standard)
    		Antagonist
    Eprosartan (Standard) is the analytical standard of Eprosartan. This product is intended for research and analytical applications. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
    Eprosartan (Standard)
  • HY-B0202S4
    Irbesartan-13C,d4
    		Antagonist
    Irbesartan-13C,d4 (SR-47436-13C,d4; BMS-186295-13C,d4) is 13C-labeled Irbesartan (HY-B0202).
    Irbesartan-<sup>13</sup>C,d<sub>4</sub>
  • HY-B0202S3
    Irbesartan-d7
    		Antagonist
    Irbesartan-d7 is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.
    Irbesartan-d<sub>7</sub>
  • HY-N14205
    Cytosporin A
    		Antagonist
    Cytosporin A is a hexahydrobenzopyran derivative and an angiotensin II receptor antagonist. Cytosporin A has IC50 values of 25-30 μM and 1.5-3 μM for AT1 and AT2, respectively.
    Cytosporin A
  • HY-N14207
    Cytosporin C
    		Inhibitor
    Cytosporin C is a hexahydrobenzopyran derivative and an angiotensin II receptor inhibitor. Cytosporin C has relatively strong inhibitory activity against AT2, with an IC50 of 30-40 μM.
    Cytosporin C
  • HY-105010
    FK-739 free base
    		Antagonist
    FK-739 (free base) is an angiotensin II type 1 (AT1) receptor antagonist used in the study of hypertension.
    FK-739 free base
  • HY-P10766
    Nva-VYIHPF
    Nva-VYIHPF is an analog of Angiotensin II (HY-13948).
    Nva-VYIHPF
  • HY-W738639
    18-Hydroxy-11-deoxy corticosterone
    18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields.
    18-Hydroxy-11-deoxy corticosterone
  • HY-17005S
    Olmesartan medoxomil-d6
    		Inhibitor
    Olmesartan medoxomil-d6 (CS 866-d6) is the deuterium labeled Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM[1][2].
    Olmesartan medoxomil-d<sub>6</sub>
  • HY-129206
    Locicortolone
    		Inhibitor
    Locicortolone (RU-24476) is a synthetic steroid compound. Locicortolone inhibits Angiotensin I (AI) induced pressor response. Locicortolone can be used in antihypertensive studies.
    Locicortolone
  • HY-17512AS
    Losartan-d6 hydrochloride
    		Antagonist
    Losartan-d6 hydrochloride is deuterated labeled Losartan potassium (HY-17512A). Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.
    Losartan-d<sub>6</sub> hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Angiotensin Receptor Isoform Comparison

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